Would it be possible to create something similar to this grid-box layout using Twitter's Bootstrap?

Here is the website I'm on about as an example. I'm not so fussed on the animations, just the generic feel of the different sized boxes on their homepage?

I'm wanting to create it in bootstrap so it can be quick. I'm not getting paid much at all for it as they're a family friend however I would still want it to look decent.

If it can't be created in bootstrap, are there any other methods/techniques you'd recommend to get the desired effect?

Thanks!

Epic visual tool

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